A condição oxidativa e a funcionalidade de indivíduos hospitalizados parece estar mais comprome-tida do que naqueles internados devido ao contágio por SARS-CoV-2

Abstract

Introduction: Many infected by Covid-19 required intensive care and remain with functional changes to this day. Objective: To investigate possible functional impairments and oxidative stress generated from SARS-CoV-2 infection in those individuals who required ICU admission. Material and method: 95 individuals participated in the study (42 covid ICU and 53 adult ICU), who were evaluated at the time of admission and followed up until they presented a clinical outcome. Assessments were related to functionality, mobility, muscle strength, oxidative stress markers and mortality predictors. Results: Regarding oxidative stress, patients admitted to the adult ICU showed greater protein damage in the last evaluation (p=0,043), higher frequency of MN (p=0,015) and increased levels of SAC (p=0,002) and GSH (p<0,0001) than those admitted to the covid ICU. Individuals with Covid-19 showed muscle weakness at the last assessment (dynamometry at R and L (p=0,019 and p=0,018, respectively)) and a reduction in mobility (p=0,002), while individuals admitted to the adult ICU showed an increase in mobility in the last assessment (p<0,0001). When comparing the two ICUs, patients hospitalized due to Covid-19 were discharged from hospital with greater functionality (p=0,041) and they also had greater mobility when they were hospitalized (p<0,0001) and adult ICU individuals were associated with greater mobility in the last evaluation (p=0,049). Conclusion: Individuals admitted to the adult ICU showed higher oxidative stress, suggesting that oxidative stress may be related to other factors and not to a specific pathology.