Avaliação dos efeitos da semente de Linum usitatissimum l. em pacientes com síndrome metabólica

Abstract

People have increasingly sought to obtain functional foods in a more healthy and balanced diet. Among these foods, linseed has been widely studied due to its ability to improve anthropometric, biochemical and oxidative stress parameters. Studies in humans and animals indicate that increased intake of linseed is inversely related to the symptoms of metabolic syndrome (MS), a multifactorial metabolic disorder that is growing rapidly, becoming of great concern. The aim of this study was to evaluate the effects of supplementation with golden linseed for 28 days on blood pressure, anthropometric, biochemical and oxidative stress parameters in patients with MS. For this, we selected 20 patients with MS and 24 healthy volunteers (control) , which received aliquots of 40g of golden linseed for daily consumption for 28 days. Fasting blood samples and anthropometric and blood pressure parameters were measured before and after the supplementation period . Biochemical analyzes included lipids and glucose, cardiac and renal markers and oxidative stress parameters. Moreover, phytochemical analysis of golden linseed and analysis of its antioxidant activity was evaluated in vitro. The results showed high concentrations of polyphenolic compounds, and a high antioxidant capacity in vitro of the golden linseed. Serum analyzes showed significant reductions (p < 0.05) in lipid and glycemic profiles, in heart and kidney markers and in oxidative damage to lipids and proteins. Furthermore, a significant improvement (p <0.05) in the enzymatic and non-enzymatic antioxidant defenses was observed. No significant differences were found in anthropometric parameters, blood pressure and oxidative DNA damage. Thus, the results suggest that the golden linseed can be used as an adjunct in the treatment of patients with MS, as it improves biochemical and oxidative stress parameters.