Desenvolvimento de formulações veganas nanotecnológicas para veiculação cutânea de resveratrol

Abstract

The cosmetics industry is continually searching for innovations that are connected to consumer appeals. These, in turn, have sought products that meet the requirements of the so-called Clean Beauty, based on the use of natural raw materials combined with the absence of animal testing. [...] This work developed a vegan lipid nanoparticle consisting of natural raw materials — cupuaçu butter and buriti oil — to encapsulate resveratrol. The results showed that the nanoparticles had nanometric size, high surface charge, pH suitable for skin application, and antioxidant activity greater than or equal to the free active ingredient. [...] In in vitro permeation tests, a lower permeation flux and amount were observed for the free active compared to that from the nanoparticles, suggesting retention within the carriers. Finally, semi-solid formulations with adequate thixotropic characteristics were prepared for topical application. This study demonstrated the preparation of innovative vegan cosmetic formulations for the prevention of skin aging.