Nanopartículas poliméricas contendo própolis e resveratrol: desenvolvimento, caracterização físico-química e avaliação antioxidante

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin condition with high prevalence, especially in children. Conventional treatments, such as corticosteroids, can lead to long-term adverse effects. In this context, resveratrol (RES), a polyphenol with therapeutic properties, and propolis, with antimicrobial, antioxidant, and healing actions, emerge as promising alternatives. However, both substances have low solubility and stability, limiting their clinical application. This study aimed to develop polymeric nanoparticles co-encapsulating RES and propolis (NPRES) as a therapeutic strategy for AD and to evaluate their antioxidant activity. The nanoparticles were prepared by interfacial deposition of preformed polymer and presented slightly acidic pH, particle size below 225 nm, negative zeta potential, and high encapsulation efficiency (>88%). The formulations preserved antioxidant activity, and in vitro release studies showed controlled RES release. Hydrogels containing NPRES maintained particle profile and appropriate pH for topical use. Therefore, these formulations are promising colloidal systems for topical application and AD treatment.