Caracterização da toxicidade do óleo de baru (Dipteryx alata) em camundongos Swiss machos

Abstract

The Baru (Dipteryx alata) is an abundant occurrence of fruit in the Brazilian cerrado. Almond is very consumed by humans for presenting pleasant taste similar to peanuts. Baru almond is produced a fine oil with a high degree of establishment, being rich in fatty acids such as oleic and linoleic, and the presence of tocopherol. Isolated reports based on home medicine suggest that the oil extracted from the almond has important benefits, particularly antioxidant, anti-inflammatory and antirreumática Several studies featuring baru as their physicochemical aspects and composition of active substances present, but there are few studies related to it is toxic effects in vivo, either in experimental animals and/or humans. Thus, this study aimed to check liver and kidney toxicity baru oil in mice. Used 20 mice Swiss young males divided into 4 groups (n = 5): group 1 (control group), group 2 (baru 5 mg/Kg), group 3 (baru 10 mg/Kg) and group 4 (Baru 50 mg/Kg). Baru oil at doses of 5, 10 and 50 mg/Kg and vehicle (canola oil - 10 mL/Kg) were administered orally by gavage for 30 consecutive days. After 24 hours from the administration of the natural compound or canola oil, all animals received a dose of pentobarbital (180 mg/Kg intraperitoneally) and blood was collected by cardiac puncture for subsequent biochemical analysis. They were evaluated biochemical parameters: TGO (transaminase glutamic oxaloacetic), TGP (transaminase glutamic pyruvic transaminase), GGT (Gamma glutamyl transferase), ALP (alkaline phosphatase), AML (amylase), urea, creatinine and Total Protein. Pretreatment with oil Baru, in general, do not cause liver and kidney toxicity proving to be a possible alternative therapy to be studied in more detail.