Exposição pré-natal e perinatal à dieta hiperlipídica induz comportamento tipo-ansioso, alterações metabólicas na prole de camundongos

Abstract

Obesity is related to chronic inflammatory state and has been associated with behavioral and anxiety alterations. Previous study have indicated that chronic high fat consumption leads to systemic inflammation and alterations in metabolism in humans and animal models. Here, we investigated the impact of maternal high fat diet (HFD) during pregnancy and lactation on offspring behavior (anxiety-like behavior), and biochemical (triglycerides, cholesterol, glucose and corticosterone) and inflammatory (tumor necrosis factorα (TNFα), interleukin-1β (IL-1β) and 6 (IL-6)) plasmatic markers in mice. We found that maternal HFD increased weight gain and anxiety in female offspring. Additionally, offspring (female and male) from HFD-fed dams also exhibited increased biochemical (triglycerides, cholesterol, glucose and corticosterone) and inflammatory (TNFα, IL-1β and IL-6) plasmatic levels. These data indicate that maternal HFD acts as a prenatal/perinatal insult that significantly impacts offspring behavior, metabolism and inflammation. In conclusion, these results suggest that prenatal and perinatal care is one of the most sensitive periods, which may contribute to the future of individuals and disorders in a critical period in development and may compromise their health. Consequently, nutritional assistance in gestation can provide access to useful knowledge about the risk of metabolic disorders and mental health.