Efeito do gama orizanol nos parâmetros oxidativos, endócrinos e bioquímicos de camundongas ovariectomizadas

Abstract

The increase of the life expectancy, especially in female sex, it has become a global phenomenon. This means that women passed to live longer with the effects of menopause, characterized by the cessation of menstruation and decline of the hormone estrogen. The estrogen deficiency it is related to various symptoms and changes in lipid and glucose profile, which can be minimized with hormonal therapies and some drugs. But, present side effects and as alternative for the treatment, stands out the administration of the gamma-oryzanol, a mixture of ferulic acid esters of phytosterols and triterpenic alcohols. Considered the phytosterol potent hypolipidemic with hypolipidemic properties, anti inflammatory and antioxidant. In this sense, the objective of this project is to evaluate the effect of gamma-oryzanol on physiological changes occurring in a postmenopausal experimental model in mice plasma. Methods: 32 female Swiss albino mice were used, were divided into 4 groups. The gamma-oryzanol at a dose of 50 mg/kg and vehicle (canola oil - 10 ml/kg) are administered orally via gavage for 28 consecutive days. Being that one day before the initiation of treatment, the animals were submitted to surgery. And after 28 days, the o blood of the animals was collected by cardiac puncture for the analysis of oxidative, endocrine and biochemical parameters. During the experimental period, the groups submitted to ovariectomy or sham surgery, presented increase of the body weight, decrease in levels of estrogen and increase in levels of glucose, insulin, cholesterol and lipid fractions. The administration of gamma-oryzanol it was effective in reversal these levels and responsible for increasing of the total reactive antioxidant potential and decrease of reactive species of oxygen, evidencing its important protective effect. Therefore, the gamma-oryzanol promoted essential metabolic improvements in maintaining the lipid profile, glycemic and other benefits related to their antioxidant capacity. Thus, an excellent therapeutic alternative for the treatment of complications present in postmenopausal, as well as, avoid a picture of metabolic syndrome, well prevalent in women during this period.