Produção de biofilmes à base de Quitosana para a liberação controlada de Naproxeno

Abstract

Release devices controlled drug release devices are primarily intended to minimize the need for toxic doses and to provide a better control of the release of the active ingredient over the course of treatment. Naproxen™ is a non-steroidal antiinflammatory drug (NSAID), analgesic and antipyretic, used for the treatment of rheumatic diseases and acute inflammatory processes. In this context, this work aimed to obtain chitosan biofilms for the controlled release of Naproxeno™. The films were prepared by the solvent evaporation method, by dissolving the chitosan in acetic acid (1% v/v), to a final concentration of the polymer solution (1% m/v), followed by the incorporation of Naproxeno™ (1 mg/ml). Chitosan was analyzed for its degree of deacetylation, while Naproxen™ was quantitatively evaluated for the active principle present in each tablet. Biofilms were characterized by crystallinity, Xray diffractometer (XRD), ultraviolet-visible (UV-Vis) spectroscopy, water vapor permeability, release profile, dissolution, in addition to the tensile test and film thickness. In the XRD assay it was observed that the incorporation of the drug in the chitosan solution allowed the reduction of the crystallinity of the membrane. In the release assay, it was evidenced that chitosan played a fundamental role in the modulation of the drug release profile, allowing the detection of Naproxen™ and indicating promising in the development of biofilms to be used as controlled drug release devices. It is also noted that biofilms exhibited tension properties, not compatible and suitable for use as devices for controlled release of drugs. Dissolution results demonstrated that the material is hydrophilic in character. It was concluded that the system presented homogeneity and adequate chemical interaction between the constituents and it was possible to obtain chitosan-based biofilms for the controlled release of Naproxen™.