Efeitos do exercício físico e enriquecimento ambiental durante a gestação na modulação dos déficits de memória e comportamento de mães e da prole em um modelo de privação maternal

Abstract

Early-life maternal separation (MS) causes memory deficits that can persist throughout life; maternal exercise (ME) during pregnancy can prevent these deficits. [...] Environmental enrichment (EE), like exercise, protects MS animals from memory deficits, suggesting a potential beneficial effect of EE during pregnancy on offspring memory. [...] MS increases self-grooming in mothers. Stopping or reducing exercise intensity during pregnancy causes detraining in mothers, leading to object recognition deficits after weaning. Maintaining intensity or starting exercise during pregnancy prevents memory deficits. [...] MS causes memory deficits only in male offspring, not females. Stopping exercise alone during pregnancy leads to OR deficits in male offspring and memory deficits in PRE+MS females in adulthood. [...] Gestational EE protected male MS offspring from spatial learning and memory deficits. Cannabinoid agonist worsened memory in MS males but improved learning in control females. We conclude that maintaining or initiating physical activity during pregnancy and gestational EE are effective strategies for protecting mothers and offspring from MS-induced memory damage.