Efeito do exercício anaeróbico sobre parâmetros bioquímicos e comportamentais em modelo de mania induzido por ouabaína

Abstract

Bipolar disorder is a syndrome that affects the central nervous system, mainly causing impactful changes in the mood of affected individuals, ranging from states of mania, hypomania, depression and euthymia. Studies suggest that the pathophysiology of the syndrome is related to a decrease in Na+,K+-ATPase activity and an increase in GSK-3β. In the present work, we used the model of mania in rats to analyze the effects of anaerobic exercise training on neurochemical and behavioral deficits induced by ouabain injection. Anaerobic exercise was not able to prevent the hyperlocomotion induced in rats by ouabain injection, since there was no manic behavior in rats, but depressive behavior. Thus, anaerobic exercise prevented depression symptoms by increasing the enzymatic activity of Na+,K+-ATPase. Furthermore, training with anaerobic exercise increased AKT content and increased GSK-3β in rat hippocampus by ouabain were not detected. This antidepressant effect occurred through increased Na+,K+-ATPase, AKT activation in trained rats, as well as greater mTOR activation, which are possible modulators of the training effect on anti-inflammatory potentials and neural resilience such as BDNF.