Estudo e elaboração de materiais informativos sobre o uso de terapia antirretroviral associada com os principais medicamentos utilizados por pessoas vivendo com HIV/AIDS

Abstract

The HIV virus affects millions of people around the world. Its Evolution usually generates systemic damage to the immune system and general impairment in human health. The main objectives of this research were to evaluate data available in the scientific literature on possible drug interactions between patients living with HIV/AIDS in concomitant use of antiretroviral therapies and some psychotropic drugs, and also to propose the development of an educational didactic material for professionals, the general public and patients living with HIV/AIDS. Initially, a bibliographic study of the integrative literature review type was carried out, evaluating different scientific publications between the years 2016 to 2022, in indexed databases such as: PubMEd, Scielo, Embase. Four articles dealing with possible drug interactions between antiretroviral therapy and psychotropic drugs, such as anticonvulsants, were evaluated. Subsequently, two booklets were prepared, one exclusively for patients using ART, a practical guide for the use and care of ART, and the other for medical professionals with updated information about the HIV virus and its possible drug interactions due to existing treatment. It was possible to identify that few studies are carried out with possible drug interactions between antiretroviral therapy and psychotropic drugs used concomitantly in patients living with HIV/AIDS. Still, it was possible to create a current teaching material that can help in the dissemination of relevant information about the HIV virus. We can observe that the report of the occurrence of drug interactions is frequent in patients diagnosed with HIV/AIDS, especially with psychotropic and anticonvulsant drugs such as Carbamazepine. Therefore, it is essential that these interaction criteria are taken into account when choosing these drugs for patients with HIV/AIDS and that, in the case of concomitant use, careful monitoring of this drug interaction is always carried out with the entire health team involved in patient treatment.