Inibição da indoleamina 2,3-dioxigenase por 1-metil triptofano atenua o comportamento agressivo induzido pelo tratamento com estanozolol em camundongos

Abstract

Anabolic androgenic steroids (AAS) are synthetic compounds derived from testosterone. They have effects that intensify a fabric construction and as masculine characteristics. In search of increased strength, body mass gain and aesthetic appeal, these substances are used indiscriminately by adolescents and athletes in high-performance sports. However, growing evidence suggests that these drugs bring undesirable side effects, such as loss of impulse control and increased aggressiveness and violence. The involvement of serotonin (5-HT, 5- hydroxytryptamine) with aggressive behavior of great relevance. In the first step of kynurenine pathway (KP), an IDO (indoleamine 2,3 dioxygenase) enzyme has a function of regulating a conversion ratio of TRP (tryptophan) to quinurenine (QUIN). An increase in enzyme activity may result in the reduction of TRP and increase QUIN, with consequent reduction of 5-HT and increase of other metabolites such as quinolic acid (AQ) that has a toxic effect on the central nervous system (CNS), causing inflammations. (1-methyltryptophan) is able to revert the behavioral and neurochemical effects caused by treatment with Stanozolol (50mg / kg / day) in mice.