Potencial neuroprotetor da Camellia sinensis e do exercício físico em um modelo de doença de Alzheimer

Abstract

Alzheimer's disease (AD) causes cognitive and memory deficits, and other. The mechanism of AD onset includes inflammatory processes and oxidative stress due to the accumulation of β-amyloid protein in the brain. Teas from Camellia sinensis and physical exercise are effective neuroprotective strategies in several models of cognitive deficits. However, it is unclear whether Camellia sinensis tea varieties have the same neuroprotective potential in AD, as well as whether different exercise configurations have the same neuroprotective potential in AD. Additionally, few studies investigated prevention strategies in AD models associated with additional risk factors, such as a hypercaloric diet. Here we determine the neuroprotective potential of different teas from Camellia sinensis and different exercise configurations in a model of AD associated or not to a hypercaloric diet. After completing a serie of biochemical and behavioral experiments, we conclude (a) that green tea has the greater neuroprotective potential in the AD model, (b) a hypercaloric diet associated with the AD model did not potentiate cognitive deficits and oxidative damage in the hippocampus, and (c) strength exercise has neuroprotective potential in the AD model studied, being the only exercise also influencing the cholinergic system.