Efeito de nanocápsulas contendo curcumina diante das alterações neurocomportamentais e teciduais em um modelo de Doença de Alzheimer em roedores

Abstract

Alzheimer's disease (AD) has become prevalent in the elderly population, causing brain alterations such as the accumulation of β-amyloid peptide in senile plaques, which leads to neurodegeneration, neuroinflammation and increased oxidative stress. [...] The aim of this study was to evaluate the effect of NC containing CURC on tissue and mnemonic alterations in an experimental model of AD in rodents. [...] The results showed that there was no damage to the locomotor activity or spatial memory of the animals in any of the groups. The evaluation of memory in the ORT revealed that the animals receiving STZ-ICV had a decline in memory and the treatments with CURC (in oil) and CURC NC were effective in reversing this effect, indicating an improvement in long-term memory. [...] Based on these results, we demonstrate that treatment with CURC and CURC NC restored memory in rats, which was impaired by STZ-ICV, and that treatment with CURC NC was effective in restoring tissue markers of oxidative stress and neuroinflammation.