Processos de purificação da água para indústria farmacêutica

Abstract

The water purification process for pharmaceutical use is based on the elimination of physicochemical, biological and microbial impurities until the required levels are obtained in the legislation approved by the health authorities. Purified water is the raw material used in around 90% of products manufactured in the pharmaceutical industry. Considering the importance of quality control in the water production system, this work aims to study the water purification processes for use in the pharmaceutical industry available in the literature and compare them with companies in the pharmaceutical sector in the city of Bagé-RS. Therefore, a literature review was carried out covering topics such as the pharmaceutical industry, types of water for pharmaceutical purposes, purification processes for these waters, and the legislation of the pharmaceutical sector. Practical cases of pharmaceutical companies were researched in order to know the main water purification methods used. Two manipulation pharmacies in Bagé were visited and interviews were carried out with their respective technicians, in order to understand the water purification processes used, in addition to the quality control of purified water. As a result of the surveys, interviews and visits to the Bagé compounding pharmacies, in conjunction with the legislation, an analysis and reflection on the procedure used in practice for water purification. The manipulation pharmacies visited are supplied with drinking water treated by the municipal public supply system, being stored in water tanks, which are regularly sanitized. The water purification process used is reverse osmosis, and the physical-chemical analyzes carried out to control water quality are carried out by outsourced companies. Many similarities were found between the procedures used in the compounding pharmacies visited and the practical cases researched. It is concluded that water is a fundamental raw material for the production of processed products, and must be purified according to the level required for its application, as recommended by law.