Dietas hipercalórica e hiperlipídica induzindo obesidade: comparando os resultados e ratos

Abstract

Obesity is characterized by excess fat in tissues that can lead to health changes. The induction of obesity by different diets in animal models mimics the metabolic changes in a similar way to humans. To use and compare two types of diets, one hypercaloric and one hyperlipidemic, and to verify which may provide more prominent results in the induction of obesity in rats. Method: Thirty-two Wistar rats were divided into three groups: control, hyperlipidic (HF) and hypercaloric (CF), baseline and post-induction weekly assessments of body weight, chest circumference (CT), naso- anal, perigonial and retroperitoneal fat and liver fat, adiposity index and biochemical blood tests. Results: All diets showed a significant increase in fat weight and adiposity index, as well as in the values of total cholesterol, low density liprotein (LDL), triglycerides, glucose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). However, only the CF group presented significant weight gain.The hypercaloric diet (CF) was more efficient in the induction of obesity in rats when compared to the hyperlipid diet (HF).