Polimorfismo adipoq +45>g do gene da adiponectina e fatores de riscos cardiometabólico em pequenos produtores rurais de uma comunidade do interior do RS

Abstract

Different factors of a physical, chemical, biological and ergonomic nature can affect the health of rural workers and impact their work activities, contributing to the development of chronic diseases. Associated with this, the prevalence of obesity is increasing in the general population, including in rural areas. Expansion of abdominal fat may alter the secretion of adipokines by adipose tissue, increasing the risk of metabolic comorbidities and cardiovascular events. Genetic factors, such as those affecting adiponectin levels, may also influence such conditions. The present study aimed to evaluate the association between genotypic variants of the + 45T> G polymorphism of the adiponectin gene and cardiovascular risk markers in small farmers. Participants answered questionnaire about health status and work practices. Anthropometric, hematological, biochemical and interleukin-6 levels were evaluated. The ADIPOQ + 45T> G polymorphism was determined by the PCR-RFLP technique. A total of 82 farmers participated in the study, 20.74% with BMI consistent with obesity, 37.80% were overweight and 41.46% were eutrophic. The allelic and genotypic frequencies found were in Hardy-Weinberg equilibrium. The results of this study did not show a significant relationship between polymorphism and overweight, nor was it related to chronic diseases and laboratory measures, except albumin and total proteins (p <0.05). IL-6 levels also did not change according to genotype, anthropometric measures and labor practices. Thus, it is possible to affirm that there was no association between ADIPOQ + 45T> G polymorphism, obesity and cardiovascular risk markers in this population of farmers. Interleukin-6 levels were also not altered in situations of potential inflammation. Additional assessments are needed to better understand the effects of this polymorphism on human health.