Interação entre a exposição ao Ferro (II) e um modelo de agregação do peptídeo β-amiloide em Caenorhabditis elegans

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Pathological features of AD include extracellular amyloid aggregates and tau protein aggregation. This study evaluated the effects of early iron exposure in Caenorhabditis elegans, a model expressing human β-amyloid in muscle cells. High iron concentrations increased paralysis, oxidative stress, and reduced lifespan without changing amyloid aggregation, indicating that free iron may accelerate the paralysis phenotype in Caenorhabditis elegans.